St. John’s wort is most commonly used for depression and conditions that accompany it such as anxiety, tiredness, loss of appetite and trouble sleeping. There is strong scientific evidence that it is effective for mild to moderate depression.

Other uses include heart palpitations, symptoms of menopause, attention deficit-hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and seasonal affective disorder (SAD).

St. John’s wort has been used for exhaustion, to stop-smoking, fibromyalgia, chronic fatigue syndrome (CFS), migraine and other types of headaches, muscle pain, nerve pain, and irritable bowel syndrome. It is also used for cancer, HIV/AIDS, and hepatitis C.﻿﻿